Attempting to synthesize lasso peptides using high pressure

Mateusz Waliczek, Magdalena Wierzbicka, Maciej Arkuszewski, Monika Kijewska, Lukasz Jaremko, Priyadharshni Rajagopal, Kacper Szczepski, Amanda Sroczyńska, Mariusz Jaremko, Piotr Stefanowicz

Research output: Contribution to journalArticlepeer-review

Abstract

Lasso peptides are unique in that the tail of the lasso peptide threads through its macrolactam ring. The unusual structure and biological activity of lasso peptides have generated increased interest from the scientific community in recent years. Because of this, many new types of lasso peptides have been discovered. These peptides can be synthesized by microorganisms efficiently, and yet, their chemical assembly is challenging. Herein, we investigated the possibility of high pressure inducing the cyclization of linear precursors of lasso peptides. Unlike other molecules like rotaxanes which mechanically interlock at high pressure, the threaded lasso peptides did not form, even at pressures the high pressure up to 14000 kbar.
Original languageEnglish (US)
Pages (from-to)e0234901
JournalPLOS ONE
Volume15
Issue number6
DOIs
StatePublished - Jun 24 2020

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