Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy

Camille Pouchol, Jean Clairambault, Alexander Lorz, Emmanuel Trélat

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We consider a system of two coupled integro-differential equations modelling populations of healthy and cancer cells under chemotherapy. Both populations are structured by a phenotypic variable, representing their level of resistance to the treatment. We analyse the asymptotic behaviour of the model under constant infusion of drugs. By designing an appropriate Lyapunov function, we prove that both cell densities converge to Dirac masses. We then define an optimal control problem, by considering all possible infusion protocols and minimising the number of cancer cells over a prescribed time frame. We provide a quasi-optimal strategy and prove that it solves this problem for large final times. For this modelling framework, we illustrate our results with numerical simulations, and compare our optimal strategy with periodic treatment schedules.
Original languageEnglish (US)
Pages (from-to)268-308
Number of pages41
JournalJournal de Mathématiques Pures et Appliquées
Volume116
DOIs
StatePublished - Oct 27 2017

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