TY - JOUR
T1 - Asymmetric Three-Component Heck/Amination of Nonconjugated Cyclodienes.
AU - Zhou, Jianrong Steve
AU - Zhu, Daoyong
AU - Chi, Yonggui Robin
AU - Jiao, Zhiwei
AU - Goncalves, Theo
AU - Huang, Kuo-Wei
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge financial support from Peking University Shenzhen Graduate School, Shenzhen Bay Laboratory(21230011-Scripps), Nanyang Technological University, GSK-EDB Trust Fund (2017 GSK-EDB Green andSustainable Manufacturing Award) and A*STAR Science andEngineering Research Council (AME IRG A1783c0010).
PY - 2020/1/22
Y1 - 2020/1/22
N2 - Asymmetric Heck/amination of nonconjugated cyclodienes proceeds to give substituted cyclohexenylamines in good enantioselectivity and exclusive trans configurations. Substituted chiral cyclohexylamines are becoming increasingly important in drug discovery. Suitable amines in this reaction include primary and secondary anilines, indoline and benzylamines. A weakly-donating diphosphite, Kelliphite forms a deep unsymmetrical pocket, which is essential for stereoselective anti-attack of external amines.
AB - Asymmetric Heck/amination of nonconjugated cyclodienes proceeds to give substituted cyclohexenylamines in good enantioselectivity and exclusive trans configurations. Substituted chiral cyclohexylamines are becoming increasingly important in drug discovery. Suitable amines in this reaction include primary and secondary anilines, indoline and benzylamines. A weakly-donating diphosphite, Kelliphite forms a deep unsymmetrical pocket, which is essential for stereoselective anti-attack of external amines.
UR - http://hdl.handle.net/10754/661338
UR - http://doi.wiley.com/10.1002/anie.201915864
UR - http://www.scopus.com/inward/record.url?scp=85079427805&partnerID=8YFLogxK
U2 - 10.1002/anie.201915864
DO - 10.1002/anie.201915864
M3 - Article
C2 - 31965664
JO - Angewandte Chemie (International ed. in English)
JF - Angewandte Chemie (International ed. in English)
SN - 1433-7851
ER -