Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles

Ruediger Borrmann, Nils Knop, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

An enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.
Original languageEnglish (US)
Pages (from-to)798-801
Number of pages4
JournalChemistry - A European Journal
Volume23
Issue number4
DOIs
StatePublished - Dec 15 2016

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