Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines

Hong Hou, Shaoqun Zhu, Iuliana Atodiresei, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The asymmetric α-alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible-light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).
Original languageEnglish (US)
Pages (from-to)1277-1280
Number of pages4
JournalEuropean Journal of Organic Chemistry
Volume2018
Issue number10
DOIs
StatePublished - Mar 14 2018

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