Asymmetric calcium catalysis: Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group

Magnus Rueping*, Teerawut Bootwicha, Supakeat Kambutong, Erli Sugiono

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Enantioselective calcium-catalyzed addition reactions of styrene and indole derivatives with trifluoropyruvates have been developed. The alkaline-earth metal-catalyzed reactions proceed smoothly to afford the corresponding products in high yields and with good to excellent enantioselectivities under mild reaction conditions.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalChemistry - An Asian Journal
Volume7
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • 1,2-addition reactions
  • asymmetric synthesis
  • brø nsted acids
  • calcium
  • chirality

ASJC Scopus subject areas

  • Chemistry(all)

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