Asymmetric Brønsted acid-catalyzed intramolecular aza-michael reaction - Enantioselective synthesis of dihydroquinolinones

Magnus Rueping*, Stefan A. Moreth, Michael Bolte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The enantioselective synthesis of 2-aryl-substituted 2,3-dihydroquinolin-4- ones, a class of heterocyclic compounds with interesting biological activities, has been achieved through a Brønsted acidcatalyzed enantioselective intramolecular Michael addition. The products are available in moderate to high yields and with good enantioselectivities.

Original languageEnglish (US)
Pages (from-to)1021-1029
Number of pages9
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume67
Issue number10
DOIs
StatePublished - Oct 1 2012

Keywords

  • Aza-Michael addition
  • Brønsted acid
  • Dihydroquinolin-4-ones
  • N-triflyl phosphoramide

ASJC Scopus subject areas

  • Chemistry(all)

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