A new enantioselective Brønsted acidcatalyzed Friedel-Crafts reaction of indole with cyclic imines has been develeoped. This organocatalytic reaction provides for the first time optically active indolindolinone derivatives in high yields and with excellent enantioselectivities (up to 91% ee) under mild reaction conditions.
- BINOL phosphate
- Enantioselective Friedel-Crafts reaction
- Quaternary carbon centers
ASJC Scopus subject areas
- Organic Chemistry