TY - JOUR
T1 - Asymmetric Brønsted acid catalysis
T2 - Catalytic enantioselective synthesis of highly biologically active dihydroquinazolinones
AU - Rueping, Magnus
AU - Antonchick, Andrey P.
AU - Sugiono, Erli
AU - Grenader, Konstantin
PY - 2009/1/19
Y1 - 2009/1/19
N2 - (Chemical Equation Presented) Surprisingly straightforward: A metal-free, highly enantioselective Brønsted acid catalyzed condensation/addition reaction has been developed for the construction of 2,3-dihydroquinazolinones starting from 2-aminobenzamide and aldehydes (see scheme). This efficient approach provides 2,3-dihydroquinazolinones with a strong preference for the S enantiomers, which have higher biological activities than the R enantiomers.
AB - (Chemical Equation Presented) Surprisingly straightforward: A metal-free, highly enantioselective Brønsted acid catalyzed condensation/addition reaction has been developed for the construction of 2,3-dihydroquinazolinones starting from 2-aminobenzamide and aldehydes (see scheme). This efficient approach provides 2,3-dihydroquinazolinones with a strong preference for the S enantiomers, which have higher biological activities than the R enantiomers.
KW - Antitumor agents
KW - Inhibitors
KW - Organocatalysis
KW - Phosphoric acid diester
UR - http://www.scopus.com/inward/record.url?scp=58349118504&partnerID=8YFLogxK
U2 - 10.1002/anie.200804770
DO - 10.1002/anie.200804770
M3 - Article
C2 - 19101974
AN - SCOPUS:58349118504
VL - 48
SP - 908
EP - 910
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
SN - 1433-7851
IS - 5
ER -