Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.

Chang Lun Shao, Chang Yun Wang, Mei Yan Wei, Yu Cheng Gu, Zhi Gang She, Pei-Yuan Qian, Yong Cheng Lin

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)690-693
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume21
Issue number2
DOIs
StatePublished - Jan 2011
Externally publishedYes

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