Applying key concepts from nature: Transition state stabilization, pre-concentration and cooperativity effects in dendritic biomimetics

Catherine Liang, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations

Abstract

Since the early days of dendrimers, their role as synthetic macromolecular catalysts has been of great interest. The attraction towards these materials is attributed in part to their hierarchical, organized architecture and globular shape. In addition, dendrimers are unique amongst synthetic macromolecules for their structural precision and the high-level of control over both functional group placement within their structure and the chemical character of the nanoenvironment they create both in their interior and at their surface. The opportunities presented by these unusual functional macromolecules have led to many studies into their use in catalytic applications, especially as synthetic enzyme mimics. Recent examples of dendrimers employing transition state stabilization, molecular pre-concentration and cooperativity between branches or surface groups to achieve enhanced reactivity will be covered in this review.

Original languageEnglish (US)
Pages (from-to)385-402
Number of pages18
JournalProgress in Polymer Science (Oxford)
Volume30
Issue number3-4
DOIs
StatePublished - Mar 1 2005

Keywords

  • Catalyst
  • Cooperativity
  • Dendrimer
  • Enzyme mimic
  • Molecular pre-concentration

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces and Interfaces
  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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