Anti-cancer activities of diospyrin, its derivatives and analogues

Sunil Sagar, Mandeep Kaur, Kenneth P. Minneman, Vladimir B. Bajic

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.
Original languageEnglish (US)
Pages (from-to)3519-3530
Number of pages12
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number9
DOIs
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Fingerprint

Dive into the research topics of 'Anti-cancer activities of diospyrin, its derivatives and analogues'. Together they form a unique fingerprint.

Cite this