Anti-Aging Strategies Based on Cellular Reprogramming

Alejandro Ocampo, Pradeep Reddy, Juan Carlos Izpisua Belmonte*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Aging can be defined as the progressive decline in the ability of a cell or organism to resist stress and disease. Recent advances in cellular reprogramming technologies have enabled detailed analyses of the aging process, often involving cell types derived from aged individuals, or patients with premature aging syndromes. In this review we discuss how cellular reprogramming allows the recapitulation of aging in a dish, describing novel experimental approaches to investigate the aging process. Finally, we explore the role of epigenetic dysregulation as a driver of aging, discussing how epigenetic reprogramming may be harnessed to ameliorate aging hallmarks, both in vitro and in vivo. A better understanding of the reprogramming process may indeed assist the development of novel therapeutic strategies to extend a healthy lifespan.

Original languageEnglish (US)
Pages (from-to)725-738
Number of pages14
JournalTrends in Molecular Medicine
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • aging
  • epigenetics
  • rejuvenation
  • reprogramming

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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