Analysis of lanthanide complex dendrimer conjugates for bimodal NIR and MRI imaging

Christopher M. Andolina, Piper J. Klemm, William C. Floyd, Jean M.J. Fréchet, Kenneth N. Raymond*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Advances in clinical diagnostic instrumentation have enabled some imaging modalities to be run concurrently. For diagnostic purposes, multimodal imaging can allow for rapid location and accurate identification of a patient's illness. The paramagnetic and near-infrared (NIR) properties of Dy(III) and Yb(III) are interesting candidates for the development of bimodal NIR and magnetic resonance imaging (MRI) contrast agents. To enhance their intrinsic bimodal properties, these lanthanides were chelated using the hexadentate-all-oxygen-donor-ligand TREN-bis(1-Me)-3,2-HOPO-TAM-NX (NX, where X = 1, 2, or 3) and subsequently conjugated to the esteramide dendrimer (EA) to improve bioavailability, solubility, and relaxivity. Of these new complexes synthesized and evaluated, DyN1-EA had the largest ionic T1 relaxivity, 7.60 mM-1 s-1, while YbN3-EA had the largest ionic T2 relaxivity with a NIR quantum yield of 0.17% when evaluated in mouse serum. This is the first Yb(III) bimodal NIR/T2 MRI contrast agent of its kind evaluated.

Original languageEnglish (US)
Pages (from-to)8982-8990
Number of pages9
JournalMacromolecules
Volume45
Issue number22
DOIs
StatePublished - Nov 27 2012

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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