An Overview of Lipid Droplets in Cancer and Cancer Stem Cells

Luca Tirinato, Francesca Pagliari, Tania Limongi, Monica Marini, Andrea Falqui, J. Seco, Patrizio Candeloro, Carlo Liberale, Enzo M. Di Fabrizio

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.
Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalStem Cells International
Volume2017
DOIs
StatePublished - Aug 13 2017

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