An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah*, Shamsuddeen A. Haladu, Basem Moosa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number2
DOIs
StatePublished - Jan 12 2011

Keywords

  • Anticancer drug
  • Azlactone formation
  • Icmt inhibitor
  • Spermatinamine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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