An efficient protocol for copper-free palladium-catalyzed Sonogashira cross-coupling in aqueous media at low temperatures

Alexander N. Marziale, Johannes Schlüter, Jörg Eppinger

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A thorough study on copper-free Sonogashira cross-couplings in water was carried out using the palla-dacycle, [{Pd(μ-Cl){K2-P,C-P(iPr) 2(OC6H3-2-Ph)}}2] as pre-catalyst with different bases and palladium concentrations. The highly active pre-catalyst imparts good to near quantitative yields using a concentration of 0.25 mol % at 40 °C. This broadly applicable protocol exhibits high tolerance of functional groups and substitution patterns. © 2011 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)6355-6358
Number of pages4
JournalTetrahedron Letters
Volume52
Issue number48
DOIs
StatePublished - Nov 2011

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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