Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides

Watchara Srimontree, Adisak Chatupheeraphat, Hsuan-Hung Liao, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a straightforward and mild fashion.
Original languageEnglish (US)
Pages (from-to)3091-3094
Number of pages4
JournalOrganic Letters
Volume19
Issue number12
DOIs
StatePublished - Jun 16 2017

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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