Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

Lloyd A. Demetrius, Pierre J. Magistretti, Luc Pellerin

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The present article appeals to these hallmarks to evaluate and contrast two competing models of AD: the amyloid hypothesis (a neuron-centric mechanism) and the Inverse Warburg hypothesis (a neuron-astrocytic mechanism). We show that these three hallmarks of AD conflict with the amyloid hypothesis, but are consistent with the Inverse Warburg hypothesis, a bioenergetic model which postulates that AD is the result of a cascade of three events—mitochondrial dysregulation, metabolic reprogramming (the Inverse Warburg effect), and natural selection. We also provide an explanation for the failures of the clinical trials based on amyloid immunization, and we propose a new class of therapeutic strategies consistent with the neuroenergetic selection model.
Original languageEnglish (US)
JournalFrontiers in Physiology
Volume5
Issue numberJAN
DOIs
StatePublished - Jan 14 2015

Fingerprint

Dive into the research topics of 'Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect'. Together they form a unique fingerprint.

Cite this