Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv)

Aubrie O'Rourke (Inventor), Stephan Georg Kremb (Inventor), Christian R. Voolstra (Inventor)

Research output: Patent

Abstract

Anti-viral compounds with low cytotoxicity are identified from screening of products found in Red Sea sponges, including the sponge Stylissa carteri. The identified compounds can be brominated pyrrole-2- aminoimidazole alkaloids and derivatives thereof. Specific examples of identified compounds include oroidin, hymenialdisine, and debromohymenialdisine, as well as derivatives thereof. The compounds also can be useful scaffolds or pharmacores for further chemical modification and derivatization. Selected compounds, particularly oroidin, show selective anti-viral HIV-1 activity coupled with reduced cytotoxicity. The compounds can function as HIV reverse-transcriptase inhibitors, and molecular modeling can be used to confirm inhibition.
Original languageEnglish (US)
Patent numberWO 2016067090 A1
StatePublished - May 6 2016

Fingerprint Dive into the research topics of 'Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (hiv)'. Together they form a unique fingerprint.

Cite this