Alginate-based hybrid aerogel microparticles for mucosal drug delivery

V. S. S. Goncalves, P. Gurikov*, J. Poejo, A. A. Matias, S. Heinrich, C. M. M. Duarte, I. Smirnova

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The application, of biopolymer aerogels as drug delivery systems (DDS) has gained increased interest during the last decade since these structures have large surface area and accessible pores allowing for high drug loadings. Being biocompatible, biodegradable and presenting low toxicity, polysaccharide-based aerogels are an attractive carrier to be applied in pharmaceutical industry. Moreover, some polysaccharides (e.g. alginate and chitosan) present mucoadhesive properties, an important feature for mucosal drug delivery. This feature allows to extend the contact of DDS with biological membranes, thereby increasing the absorption of drugs through the mucosa. Alginate-based hybrid aerogels in the form of microparticles (

Original languageEnglish
Pages (from-to)160-170
Number of pages11
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume107
DOIs
StatePublished - Oct 2016
Externally publishedYes

Keywords

  • Hybrid aerogels
  • Alginate
  • Pectin
  • Carrageenan
  • Microparticles
  • Supercritical fluid technology
  • KAPPA-CARRAGEENAN OLIGOSACCHARIDES
  • EMULSIFICATION INTERNAL GELATION
  • IN-VITRO EVALUATION
  • MUCOADHESIVE PROPERTIES
  • CHITOSAN MICROSPHERES
  • PARTICLES
  • SYSTEMS
  • BEADS
  • QUERCETIN
  • EMULSIONS

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