Aldehyde-Selective Wacker-Type Oxidation of Unbiased Alkenes Enabled by a Nitrite Co-Catalyst

Zachary K. Wickens, Bill Morandi, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Breaking the rules: Reversal of the high Markovnikov selectivity of Wacker-type oxidations was accomplished using a nitrite co-catalyst. Unbiased aliphatic alkenes can be oxidized with high yield and aldehyde selectivity, and several functional groups are tolerated. 18O-labeling experiments indicate that the aldehydic O atom is derived from the nitrite salt.
Original languageEnglish (US)
Pages (from-to)11467-11470
Number of pages4
JournalAngewandte Chemie
Volume125
Issue number43
DOIs
StatePublished - Sep 13 2013
Externally publishedYes

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