This paper presents a new framework for Traffic Flow Management and Airspace Health Monitoring based on data-driven approach for air traffic flows modeling using historical data. The large-scale 3-dimensional flow network of the Cleveland center airspace provides valuable insight on airspace complexity. A linear formulation of the Traffic Flow Management Problem is proposed, taking into account estimations of controller workload based on flow geometry. Preliminary results for the problem are discussed, pointing out clues for further research. © 2011 IEEE.