Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Olivier Sorg, Luc Pellerin, Marc Stolz, Siham Beggah, Pierre Magistretti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 μM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP Application of either arachidonic acid (AA), or certain unsaturated fatty acids, also results in glycogen breakdown. The EC50 of AA is approximately 50 μM. Thus ATP and AA can be added to the list of neuroactive agents that control glycogen levels in astrocytes, which includes noradrenaline, vasoactive intestinal peptide (VIP), adenosine and histamine.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalNeuroscience Letters
Volume188
Issue number2
DOIs
StatePublished - Mar 24 1995

Keywords

  • ATP
  • Arachidonic acid
  • Astrocytes
  • Energy metabolism
  • Glycogen
  • Purinergic

ASJC Scopus subject areas

  • Neuroscience(all)

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