Action of heptaminol hydrochloride on contractile properties in frog isolated twitch muscle fibre

Bruno Allard*, Vincent Jacquemond, Fouad Lemtiri-Chlieh, Bernard Pourrias, Oger Rougier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Heptaminol stopped or delayed the progressive decline in tension which characterizes the phenomenon of fatigue in frog isolated twitch muscle fibre. Heptaminol had no action on the sodium, potassium and calcium voltage‐dependent ionic conductances. The hypothesis of an action via an internal alkalinization was tested by comparison with the action of NH4Cl. Both substances increased the tension. The action of heptaminol was suppressed in sodium‐free (TRIS) solution or in the presence of amiloride while the action of NH4Cl was always observed. These results could be explained by a stimulation of the Na/H antiport by heptaminol. 1991 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)714-718
Number of pages5
JournalBritish Journal of Pharmacology
Volume104
Issue number3
DOIs
StatePublished - Jan 1 1991

Keywords

  • Heptaminol
  • excitation‐contraction coupling
  • fatigue
  • frog twitch muscle fibre

ASJC Scopus subject areas

  • Pharmacology

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