Acidic pH-responsive nanogels as smart cargo systems for the simultaneous loading and release of short oligonucleotides and magnetic nanoparticles

Smriti R. Deka, Alessandra Quarta, Riccardo Di-Corato, Andrea Falqui, Liberato Manna, Roberto Cingolani, Teresa Pellegrino*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Smart materials able to sense environmental stimuli can be exploited as intelligent carrier systems. Acidic pHresponsive polymers, for instance, exhibit a variation in the ionization state upon lowering the pH, which leads to their swelling. The different permeability of these polymers as a function of the pH could be exploited for the incorporation and subsequent release of previously trapped payload molecules/nanoparticles. We provide here a proof of concept of a novel use of pH-responsive polymer nanostructures based on 2-vinylpyridine and divinylbenzene, having an overall size below 200 nm, as cargo system for magnetic nanoparticles, for oligonucleotide sequences, as well as for their simultaneous loading and controlled release mediated by the pH.

Original languageEnglish (US)
Pages (from-to)10315-10324
Number of pages10
JournalLangmuir
Volume26
Issue number12
DOIs
StatePublished - Jun 15 2010
Externally publishedYes

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy
  • Medicine(all)

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