Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics

Jessica L. Cohen, Stephanie Schubert, Peter R. Wich, Lina Cui, Joel A. Cohen, Justin Lee Mynar, Jean Frechet

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.

Original languageEnglish (US)
Pages (from-to)1056-1065
Number of pages10
JournalBioconjugate Chemistry
Volume22
Issue number6
DOIs
StatePublished - Jun 15 2011

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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