Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy

Kyle E. Broaders, Joel A. Cohen, Tristan T. Beaudette, Eric M. Bachelder, Jean Frechet

Research output: Contribution to journalArticlepeer-review

206 Scopus citations

Abstract

Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that are tunable over 2 orders of magnitude depending on the degree and type of acetal modification. Varying the degradation rate produces particles that perform better than poly(lactic-co-glycolic acid) and iron oxide, two commonly studied materials used for particulate immunotherapy, in major histocompatibility complex class I (MHC I) and MHC II presentation assays. Modulating the material properties leads to antigen presentation on MHC I via pathways that are dependent or independent of the transporter associated with antigen processing. To the best of our knowledge, this is the only example of a material that can be tuned to operate on different immunological pathways while maximizing immunological presentation.

Original languageEnglish (US)
Pages (from-to)5497-5502
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number14
DOIs
StatePublished - Apr 7 2009

Keywords

  • Acid-sensitive
  • Biocompatible
  • Encapsulation
  • Polymer
  • Vaccine

ASJC Scopus subject areas

  • General

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