Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells

Joel A. Cohen, Tristan T. Beaudette, Jessica L. Cohen, Kyle E. Broaders, Eric M. Bachelder, Jean Frechet

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Figure Presented A microparticulate gene delivery system based on biodegradable and acid-sensitive acetal-modified dextran with unprecedented tunability of degradation rates and simplicity of surface functionalization is presented. When optimally formulated with small amounts of cationic polymers, these microparticles are capable of efficiently transfecting both phagocytic and nonphagocytic cells with minimal toxicity.

Original languageEnglish (US)
Pages (from-to)3593-3597
Number of pages5
JournalAdvanced Materials
Volume22
Issue number32
DOIs
StatePublished - Aug 24 2010

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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