A vision and strategy for the virtual physiological human: 2012 update

Peter Hunter*, Tara Chapman, Peter V. Coveney, Bernard de Bono, Vanessa Diaz, John Fenner, Alejandro F. Frangi, Peter Harris, Rod Hose, Peter Kohl, Pat Lawford, Keith McCormack, Miriam Mendes, Stig Omholt, Alfio Quarteroni, Nour Shublaq, John Skår, Karl Stroetmann, Jesper Tegner, S. Randall ThomasIoannis Tollis, Ioannis Tsamardinos, Johannes H.G.M. van Beek, Marco Viceconti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

European funding under Framework 7 (FP7) for the virtual physiological human (VPH) project has been in place now for 5 years. The VPH Network of Excellence (NoE) has been set up to help develop common standards, open source software, freely accessible data and model repositories, and various training and dissemination activities for the project. It is also working to coordinate the many clinically targeted projects that have been funded under the FP7 calls. An initial vision for the VPH was defined by the FP6 STEP project in 2006. In 2010, we wrote an assessment of the accomplishments of the first two years of the VPH in which we considered the biomedical science, healthcare and information and communications technology challenges facing the project (Hunter et al. 2010 Phil. Trans. R. Soc. A 368, 2595-2614 (doi:10.1098/rsta.2010.0048)). We proposed that a not-for-profit professional umbrella organization, the VPH Institute, should be established as a means of sustaining the VPH vision beyond the time-frame of the NoE. Here, we update and extend this assessment and in particular address the following issues raised in response to Hunter et al.: (i) a vision for the VPH updated in the light of progress made so far, (ii) biomedical science and healthcare challenges that the VPH initiative can address while also providing innovation opportunities for the European industry, and (iii) external changes needed in regulatory policy and business models to realize the full potential that the VPH has to offer to industry, clinics and society generally.

Original languageEnglish (US)
JournalInterface Focus
Volume3
Issue number2
DOIs
StatePublished - Apr 6 2013

Keywords

  • Computational physiology
  • Multiscale modelling
  • Physiome
  • Systems biology
  • Virtual physiological human

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

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