A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes

Hailing Jin, Jian-Kang Zhu

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

RNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.
Original languageEnglish (US)
Pages (from-to)853-856
Number of pages4
JournalGenes & Development
Volume24
Issue number9
DOIs
StatePublished - May 3 2010

ASJC Scopus subject areas

  • Medicine(all)

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