A unique trimolecular michael reaction and cyclization

Mohammad M. Al-Arab*, Bader Ghanem, Alan O. Fitton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

1,3-Diaryl-2-propene-1-ones react with ethyl cyanoacetate in presence of sodium ethoxide at room temperature to give 2-aroyl-1,3,5-triaryl-4-carbethoxy-4-cyanocyclohexanols. The structure of the reaction products was established by infrared, H-1 and C-13 nuclear magnetic resonance spectral data as well as elemental analysis. X-ray crystallography shows the presence of the cyclohexanol moeity.

Original languageEnglish (US)
Pages (from-to)6545-6552
Number of pages8
JournalTetrahedron
Volume45
Issue number20
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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