This paper addresses the case of physiological states reconstruction in a small region of the brain under modeling uncertainties. The misunderstood coupling between the cerebral blood volume and the oxygen extraction fraction has lead to a partial knowledge of the so-called balloon model describing the hemodynamic behavior of the brain. To overcome this difficulty, a High Order Sliding Mode observer is applied to the balloon system, where the unknown coupling is considered as an internal perturbation. The effectiveness of the proposed method is illustrated through a set of synthetic data that mimic fMRI experiments.
|Original language||English (US)|
|Title of host publication||22nd Mediterranean Conference on Control and Automation|
|Publisher||Institute of Electrical and Electronics Engineers (IEEE)|
|Number of pages||6|
|State||Published - Jun 2014|