A sequence-based dynamic ensemble learning system for protein ligand-binding site prediction

Peng Chen, ShanShan Hu, Jun Zhang, Xin Gao, Jinyan Li, Junfeng Xia, Bing Wang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Background: Proteins have the fundamental ability to selectively bind to other molecules and perform specific functions through such interactions, such as protein-ligand binding. Accurate prediction of protein residues that physically bind to ligands is important for drug design and protein docking studies. Most of the successful protein-ligand binding predictions were based on known structures. However, structural information is not largely available in practice due to the huge gap between the number of known protein sequences and that of experimentally solved structures
Original languageEnglish (US)
Pages (from-to)901-912
Number of pages12
JournalIEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume13
Issue number5
DOIs
StatePublished - Dec 3 2015

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