A selenocysteine tRNA and SECIS element in Plasmodium falciparum

Tobias Mourier*, Arnab Pain, Bart Barrell, Sam Griffiths-Jones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The molecular machinery for incorporating selenocysteine into proteins is present in both prokaryotes and eukaryotes. Although selenocysteine insertion has been reported in animals, plants, and protozoans, known eukaryotic selenocysteine tRNA sequences and selenocysteine insertion sequences are limited to animals and plants. Here we present clear indications of the presence of selenocysteine-tRNA and a selenocysteine insertion sequence in Plasmodium falciparum. To our knowledge, this is the first report of an identification of protozoan selenocysteine insertion machinery at the sequence level.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalRNA
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2005

Keywords

  • Apicomplexa
  • Malaria
  • Plasmodium
  • SECIS element
  • Selenocysteine

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

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