A powerful reagent for synthesis of weinreb amides directly from carboxylic acids

Teng Niu, Weimin Zhang, Danfeng Huang*, Changming Xu, Haifeng Wang, Yulai Hu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

A powerful reagent, P[NCH3(OCH3)]3 (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)]3 was heated with aromatic and aliphatic carboxyllc acids in toluene. The sterically hindered carboxyllc acids can also give the corresponding Welnreb amides In excellent yields.

Original languageEnglish (US)
Pages (from-to)4474-4477
Number of pages4
JournalOrganic Letters
Volume11
Issue number19
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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