A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins

Bettina M. Lengsfeld, Kayla N. Berry, Sharmistha Ghosh, Masateru Takahashi, Nicole J. Francis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Propagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.
Original languageEnglish (US)
JournalScientific Reports
Volume2
Issue number1
DOIs
StatePublished - Sep 17 2012

ASJC Scopus subject areas

  • General

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