A planar conducting micro-loop structure for transportation of magnetic beads: An approach towards rapid sensing and quantification of biological entities

Chinthaka Pasan Gooneratne, Ioanna Giouroudi, Jürgen Kosel

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Magnetic beads are utilized effectively in a wide variety of medical applications due to their small size, biocompatibility and large surface to volume ratio. Microfluidic lab-on-a-chip (LOC) devices, which utilize magnetic beads, are promising tools for accurate and rapid cell sorting and counting. Effective manipulation of beads is a critical factor for the performance of LOC devices. In this paper we propose a planar conducting micro-loop structure to trap, manipulate and transport magnetic beads. Current through the micro-loops produces magnetic field gradients that are proportional to the force required to manipulate the beads. Numerical analyses were performed to study the magnetic forces and their spatial distributions. Experimental results showed that magnetic beads could not only be transported towards a target region, e.g., for sensing purposes, but also the trapping rate could be increased by switching current between the different loops in the micro-loop structure. This method could lead to rapid and accurate quantification of biological entities tagged with magnetic beads. Copyright © 2012 American Scientific Publishers. All rights reserved.
Original languageEnglish (US)
Pages (from-to)770-774
Number of pages5
JournalSensor Letters
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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