A novel strategy for encapsulation and release of proteins: Hydrogels and microgels with acid-labile acetal cross-linkers

Niren Murthy, Yi X. Thng, Stephany Schuck, Ming C. Xu, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

347 Scopus citations

Abstract

A new acid-labile acetal cross-linker was synthesized and used to prepare protein-loaded hydrogels and microgels. This cross-linker undergoes an acid-catalyzed degradation with a half-life of 5.5 min at pH 5.0 and 24 h at pH 7.4. Protein-loaded hydrogels were synthesized with this cross-linker, and their release profiles were measured as a function of pH. Hydrogels made with the acetal cross-linker release their contents in a pH-dependent manner. The acetal cross-linker was also used to synthesize microgels with sizes between 1 and 10 μm, a range suitable for phagocytosis. The unique acid sensitivity of the acetal cross-linker should make it a useful synthetic intermediate in the design of acid-sensitive drug or gene delivery systems.

Original languageEnglish (US)
Pages (from-to)12398-12399
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number42
DOIs
StatePublished - Oct 23 2002

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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