Due to the emerging water crisis, the global desalination capacity has been expanding exponentially in the past few decades, leading to substantial amount of primary energy consumption. Therefore, the exploration of energy-efficient desalination processes and alternative energy sources has been the subject of great research interests. The spray-assisted low-temperature desalination (SLTD) system is a novel method for desalination that enables efficient renewable energy utilization. It works on the direct-contact spray evaporation/condensation mechanism and uses only hollow chambers. The merits include enhanced heat and mass transfer, lower initial and operational costs, and reduced scaling and fouling issues. This chapter presents a study on the SLTD system driven by sensible heat sources. The working principle of the system will be introduced first. Then a thermodynamic analysis will be presented to obtain the freshwater productivity under different design and operational conditions. Additionally, the energy utilization level will be quantified to highlight the energy wastage when operating with sensible heat sources. Afterward, the system configuration will be modified to maximize the utilization of sensible heat sources and promote productivity. Finally economic viability of the modified design will be evaluated.