A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Arnab Pain, Britta C. Urban, Oscar Kai, Climent Casals-Pascual, Juma Shafi, Kevin Marsh, David J. Roberts*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0·74, 95% CI 0·55-0·99; p=0·036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

Original languageEnglish (US)
Pages (from-to)1502-1503
Number of pages2
JournalLancet
Volume357
Issue number9267
DOIs
StatePublished - May 12 2001

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'A non-sense mutation in Cd36 gene is associated with protection from severe malaria'. Together they form a unique fingerprint.

Cite this