A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein

Ekaterina Smirnova, Jamie J. Kwan, Ryan Siu, Xin Gao, Georg Zoidl, Borries Demeler, Vivian Saridakis, Logan W. Donaldson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASKIN1, CASKIN2 cannot bind CASK due to the absence of a CASK Interaction Domain and consequently, may have evolved undiscovered structural and functional distinctions.
Original languageEnglish (US)
JournalCell Communication and Signaling
Volume14
Issue number1
DOIs
StatePublished - Aug 22 2016

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