A magnetic biosensor system for detection of E. coli

Fuquan Li, Jürgen Kosel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

This work describes a device for detecting E. coli bacteria by manipulating superparamagnetic beads to a sensing area and immobilizing them in a trapping well. The trapping well replaces the biochemical immobilization layer, which is commonly used in magnetic biosensor systems. A concept exploiting the volume difference between bare magnetic beads and magnetic bead-bioanalyte compounds is utilized to detect E. coli bacteria. Trapped beads are detected by the help of a tunnel magneto-resistive sensor. Frequency modulation is employed, in order to increase the signal-to-noise ratio, enabling the detection of individual superparamagnetic beads of 2.8 μm in diameter. Replacing the biochemical immobilization layer by the trapping well greatly simplifies the detection process. After applying the mixture of E. coli and magnetic beads to the biosensor system, bacteria detection is achieved in a single step, within a few minutes. © 2013 IEEE.
Original languageEnglish (US)
Pages (from-to)3492-3495
Number of pages4
JournalIEEE Transactions on Magnetics
Volume49
Issue number7
DOIs
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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