A Low Protein Binding Cationic Poly(2-oxazoline) as Non-Viral Vector

Zhijian He, Lei Miao, Rainer Jordan, Devika S-Manickam, Robert Luxenhofer, Alexander V. Kabanov

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Developing safe and efficient non-viral gene delivery systems remains a major challenge. We present a new cationic poly(2-oxazoline) (CPOx) block copolymer for gene therapy that was synthesized by sequential polymerization of non-ionic 2-methyl-2-oxazoline and a new 2-oxazoline monomer, 2-(N-methyl, N-Boc-amino)-methyl-2-oxazoline, followed by deprotection of the pendant secondary amine groups. Upon mixing with plasmid DNA (pDNA), CPOx forms small (diameter ≈80 nm) and narrowly dispersed polyplexes (PDI
Original languageEnglish (US)
Pages (from-to)1004-1020
Number of pages17
JournalMacromolecular Bioscience
Volume15
Issue number7
DOIs
StatePublished - Apr 2 2015
Externally publishedYes

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