A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration

Wenkun Zhou, Jose L. Lozano-Torres, Ikram Blilou, Xiaoyue Zhang, Qingzhe Zhai, Geert Smant, Chuanyou Li, Ben Scheres

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Plants are sessile and have to cope with environmentally induced damage through modification of growth and defense pathways. How tissue regeneration is triggered in such responses and whether this involves stem cell activation is an open question. The stress hormone jasmonate (JA) plays well-established roles in wounding and defense responses. JA also affects growth, which is hitherto interpreted as a trade-off between growth and defense. Here, we describe a molecular network triggered by wound-induced JA that promotes stem cell activation and regeneration. JA regulates organizer cell activity in the root stem cell niche through the RBR-SCR network and stress response protein ERF115. Moreover, JA-induced ERF109 transcription stimulates CYCD6;1 expression, functions upstream of ERF115, and promotes regeneration. Soil penetration and response to nematode herbivory induce and require this JA-mediated regeneration response. Therefore, the JA tissue damage response pathway induces stem cell activation and regeneration and activates growth after environmental stress.
Original languageEnglish (US)
Pages (from-to)942-956
Number of pages15
JournalCell
Volume177
Issue number4
DOIs
StatePublished - Apr 4 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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