A High-Resolution LC-MS-Based Secondary Metabolite Fingerprint Database of Marine Bacteria

Liang Lu, Jijie Wang, Ying Xu, Kailing Wang, Yingwei Hu, Renmao Tian, Bo Yang, Qiliang Lai, Yongxin Li, Weipeng Zhang, Zongze Shao, Henry Lam, Pei-Yuan Qian

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

© 2014 Macmillan Publishers Limited. All rights reserved. Marine bacteria are the most widely distributed organisms in the ocean environment and produce a wide variety of secondary metabolites. However, traditional screening for bioactive natural compounds is greatly hindered by the lack of a systematic way of cataloguing the chemical profiles of bacterial strains found in nature. Here we present a chemical fingerprint database of marine bacteria based on their secondary metabolite profiles, acquired by high-resolution LC-MS. Till now, 1,430 bacterial strains spanning 168 known species collected from different marine environments were cultured and profiled. Using this database, we demonstrated that secondary metabolite profile similarity is approximately, but not always, correlated with taxonomical similarity. We also validated the ability of this database to find species-specific metabolites, as well as to discover known bioactive compounds from previously unknown sources. An online interface to this database, as well as the accompanying software, is provided freely for the community to use.
Original languageEnglish (US)
JournalScientific Reports
Volume4
Issue number1
DOIs
StatePublished - Oct 9 2014
Externally publishedYes

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