A database of immunoglobulins with integrated tools: DIGIT.

Anna Chailyan, Anna Tramontano, Paolo Marcatili

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.
Original languageEnglish (US)
Pages (from-to)D1230-D1234
Number of pages1
JournalNucleic Acids Research
Volume40
Issue numberD1
DOIs
StatePublished - Nov 10 2011
Externally publishedYes

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