A biodetection method using magnetic particles and micro traps

Fuquan Li, Ioanna Giouroudi, Jürgen Kosel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The general working principle of magnetoresistive sensors for biological applications is to specifically attach bioanalytesto magnetic particles and then detect the particles that are immobilized on the sensor surface. The immobilization of the particles on the sensor surface commonly uses biomolecular interactions, e.g., antigen-antibody. Thus, the sensor surface needs to be functionalized via biological treatments in order to capture certain bioanalytes. In the presented work, a new method is proposed, which does not rely on functionalization of the sensor surface. Current carrying microstructures in combination with mechanical micro traps are used to immobilize magnetic particles. Analyte detection is based on the difference in size between bare magnetic particles and particles with analyte attached, which causes a different number of particles to be captured in the micro traps.
Original languageEnglish (US)
Pages (from-to)07B328
JournalJournal of Applied Physics
Volume111
Issue number7
DOIs
StatePublished - Mar 10 2012

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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