3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth

H. Perfahl, H. M. Byrne, T. Chen, V. Estrella, T. Alarcón, A. Lapin, R. A. Gatenby, R. J. Gillies, M. C. Lloyd, P. K. Maini, M. Reuss, M. R. Owen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.
Original languageEnglish (US)
Title of host publicationMicro and Nano Flow Systems for Bioanalysis
PublisherSpringer Nature
Pages29-48
Number of pages20
ISBN (Print)9781461443759
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

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