β-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability

Yogesh R Mahajan, Magnus Rueping, Dieter Seebach

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

b3-Homoarginine was synthesized to examine the effect of arginine side chains on b-peptides. CD spectra revealed the presence of a 314-helix in MeOH, which undergoes a transition to an unordered or less ordered conformation in aq. soln. The dispersion of the amide and side-chain NH protons was increased when moving from MeOH to a 3:1 MeOH/H2O mixt. b-Heptaarginine was obsd. to be capable of penetrating the cells and entering the nuclear compartments. [on SciFinder (R)]
Original languageEnglish (US)
Title of host publicationβ-Homoarginine-Containing β-Peptides: structure and cell-penetrating ability
Place of PublicationLaboratorium fuer Organische Chemie der Eidgenoessischen Technischen Hochschule Zuerich,ETH-Hoenggerberg,Zurich,Switz
Number of pages2
StatePublished - 2002
Externally publishedYes

Publication series

NamePeptides 2002, Proceedings of the European Peptide Symposium, 27th, Sorrento, Italy, Aug.31-Sept.6, 2002

Keywords

  • ABILITY
  • AMIDE
  • CELL
  • CELLS
  • CHAIN
  • CHAINS
  • CONFORMATION
  • Cd Spectra
  • Chemical
  • PROTEIN
  • SPECTRA
  • Structure
  • homoarginine beta peptide prepn heptaarginine cell

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